Scleredema neonatorum is a disease of skin and subcutaneous adipose sclerosis and edema caused by cold, premature delivery, infection, asphyxia and other reasons, with a high mortality rate.
The causes of neonatal scleredema are as follows:
(1) Neonates have less subcutaneous fat, poor warmth retention, relatively large body surface area, thinner skin, more blood vessels, and are easy to dissipate heat and cause low body temperature.
(2) Neonates lack the enzymes that make saturated fatty acids become unsaturated fatty acids, so the content of saturated fatty acids in subcutaneous adipose tissue is higher, the solubility point of saturated fatty acids is higher, and it is easy to coagulate when calorie is insufficient or cold.
(3) When neonates suffer from hypoxia and acidosis caused by infection, the heat production process of brown fat in neonates is inhibited, and the temperature of the body is not rising. In addition, the neonates are born soon and eat less milk, so the source of heat is insufficient, and the subcutaneous fat of BeilJ is easy to coagulate and harden.
(4) There are many red blood cells in the blood of newborns. When subcutaneous fat is coagulated due to cold and other factors, blood flow is slow, blood stasis occurs, permeability increases and edema occurs.